Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: LANA[title]

Definition / General
  • Human herpesvirus 8 (HHV8) Latency Associated Nuclear Antigen
  • Highly expressed during latent HHV8 infection
  • Interacts with pRb, which regulates beginning of S phase of cell cycle; also inhibits p53
  • Presence in serum is associated with developing Kaposi sarcoma in immunocompromised individuals
Micro Images

LANA+ Kaposi sarcoma

Positive Staining - Disease
  • HHV8 associated Kaposi sarcoma (endothelial and spindle cells, 92% sensitive and highly specific), primary effusion lymphoma, multicentric Castleman disease
Additional References