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Stains

LIN28

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 17 December 2011, last major update December 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.

Definition
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● First characterized in 2003 (Dev Biol 2003;258:432)
● RNA-binding protein that maintains pluripotency of embryonic stem cells.

Clinical features
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● May regulate glucose metabolism (Cell 2011;147:81)

Interpretation
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● Cytoplasmic staining

Uses by pathologists
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● Diagnostic marker comparable to SALL4 for germ cell tumors (testicular, ovarian and extragonadal): intratubular germ cell neoplasia, seminoma, dysgerminoma, embryonal carcinoma, yolk sac tumor (Hum Pathol 2011;42:710, Histopathology 2011;59:452, Mod Pathol 2011;24:288)

Micro images
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Dysgerminoma

Positive staining - disease
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● Germ cell tumors: intratubular germ cell neoplasia, embryonal carcinoma, seminoma, dysgeminoma, yolk sac tumor, gonadoblastoma
● Variable staining in teratoma, choriocarcinoma, spermatocytic seminoma

End of Stains > LIN28

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