Author: Nat Pernick, M.D. (see Authors page)

Revised: 6 November 2015, last major update December 2011

Copyright: (c) 2002-2015,, Inc.

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Cite this page: LIN28. website. Accessed January 22nd, 2019.
Definition / general
  • First characterized in 2003 (Dev Biol 2003;258:432)
  • RNA-binding protein that maintains pluripotency of embryonic stem cells
Clinical features
  • Cytoplasmic staining
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:
Positive staining - disease
  • Germ cell tumors: intratubular germ cell neoplasia, embryonal carcinoma, seminoma, dysgeminoma, yolk sac tumor, gonadoblastoma
  • Variable staining in teratoma, choriocarcinoma, spermatocytic seminoma