Stains
LMO2

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 December 2015, last major update October 2012

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: LMO2 [title]

Definition / General
  • LIM-only protein 2
  • Germinal center B cell marker (HGAL may be superior)
  • Regulatory protein essential for hematopoietic development
    • Inappropriate overexpression in T cells contributes to T-cell leukemia
Uses by Pathologists
Micro Images

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Follicular lymphoma LMO2+

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Nodal marginal zone lymphoma

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Germinal center-associated markers

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Lymphatic vasculature

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Myocardial vasculature

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CNS vasculature

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Benign vascular neoplasms

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Malignant vascular neoplasms

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Nonvascular malignancies

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LMO2 reactivity

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Follicular and marginal zone lymphomas

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Follicular lymphoma

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Nodular marginal zone lymphoma

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Immunohistologic comparison

Positive Staining - Normal
  • Endothelium and lymphatics, CD34+ blasts, hematopoietic precursors, various B cells (germinal center, mantle, splenic marginal zone)
  • Breast myoepithelium, prostatic basal cells, uterine secretory phase endometrial glands
Positive Staining - Disease
Negative Staining
  • Peripheral T cell lymphoma (usually)
  • Vasculature is LMO2- in adult and fetal heart, brain of older adults, hepatic sinusoids, and hepatocellular carcinoma (Am J Clin Pathol 2009;131:264)