Stains & CD markers
LMO2


Last author update: 1 October 2012
Last staff update: 2 July 2021

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PubMed Search: LMO2 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. LMO2. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainslmo2.html. Accessed March 19th, 2024.
Definition / general
  • LIM-only protein 2
  • Germinal center B cell marker (HGAL may be superior)
  • Regulatory protein essential for hematopoietic development
    • Inappropriate overexpression in T cells contributes to T-cell leukemia
Uses by pathologists
Microscopic (histologic) images

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Follicular lymphoma LMO2+

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Nodal marginal zone lymphoma

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Germinal center associated markers


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Lymphatic vasculature

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CNS vasculature

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Benign vascular neoplasms

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Malignant vascular neoplasms

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Nonvascular malignancies

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LMO2 reactivity


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Follicular lymphoma

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Nodular marginal zone lymphoma

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Immunohistologic comparison

Positive staining - normal
  • Endothelium and lymphatics, CD34+ blasts, hematopoietic precursors, various B cells (germinal center, mantle, splenic marginal zone)
  • Breast myoepithelium, prostatic basal cells, uterine secretory phase endometrial glands
Positive staining - disease
Negative staining
  • Peripheral T cell lymphoma (usually)
  • Vasculature is LMO2- in adult and fetal heart, brain of older adults, hepatic sinusoids, and hepatocellular carcinoma (Am J Clin Pathol 2009;131:264)
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