Stains & molecular markers
MALT1


Topic Completed: 1 December 2012

Minor changes: 3 September 2020

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PubMed Search: MALT1 [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. MALT1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsmalt1.html. Accessed September 28th, 2020.
Definition / general
  • Gene at 18q21 (same location as BCL2)
  • Also called paracaspase
  • Rearranged with API2 in MALT lymphoma and occasionally with IgH in diffuse large B cell lymphoma
  • Upstream of NF-κB in signaling pathway
Diagrams / tables

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Signaling pathway

Uses by pathologists
  • Part of translocations indicated below; inhibitors may ultimately be useful for diffuse large B cell lymphoma (Cancer Cell 2012;22:812)
Molecular / cytogenetics description
Molecular / cytogenetics images

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FISH analysis of API2-MALT1

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