Stains
MALT1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 November 2015, last major update December 2012

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: MALT1 [title]

Cite this page: MALT1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsmalt1.html. Accessed December 7th, 2016.
Definition / General
  • Gene at 18q21 (same location as BCL2)
  • Also called paracaspase
  • Rearranged with API2 in MALT lymphoma and occasionally with IgH in diffuse large B cell lymphoma
  • Upstream of NF-κB in signaling pathway
Diagrams / Tables

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Signaling pathway

Uses by Pathologists
  • Part of translocations indicated below; inhibitors may ultimately be useful for diffuse large B cell lymphoma (Cancer Cell 2012;22:812)
Molecular / Cytogenetics Description
Molecular / Cytogenetics Images

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FISH with MALT1

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FISH analysis of API2-MALT1