Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 29 December 2012, last major update December 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.
● Gene at 18q21 (same location as BCL2)
● Also called paracaspase
● Rearranged with API2 in MALT lymphoma and occasionally with IgH in diffuse large B cell lymphoma
● Upstream of NF-κB in signaling pathway
Uses by pathologists
● Part of translocations indicated below; inhibitors may ultimately be useful for diffuse large B cell lymphoma (Cancer Cell 2012;22:812)
● Rearrangement of MALT1 gene in occasional cases of MALT lymphoma (Arch Pathol Lab Med 2008;132:1405), lymphoplasmacytic lymphoma (Am J Surg Pathol 2008;32:1643)
● Rearrangement more common (45%) in pulmonary MALT (Hum Pathol 2011;42:1297)
● Rarely rearranged in diffuse large B cell lymphoma, cannot differentiate from IgH-BCL2 by cytogenetics (Hum Pathol 2003;34:1212, Mod Pathol 2012 Sep 28 [Epub ahead of print])
FISH with MALT1 break apart probe shows no rearrangement
Figure 2 - FISH analysis of API2-MALT1 in pulmonary MALT
End of Stains > MALT1
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