Stains
MelanA / MART1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 November 2015, last major update December 2012

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: MelanA [title]

Cite this page: MART1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsmart1.html. Accessed December 2nd, 2016.
Definition / General
  • Commonly used melanocytic markers; MelanA also called A103; are separate antibodies that occasionally have different staining properties
  • Melanocytic Antigen Recognized by cytotoxic T lymphocytes from melanoma patients
  • Cytoplasmic protein sensitive and specific for melanoma and melanocytic lesions
Uses by Pathologists
Micro Images

Images hosted on PathOut server:

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Kidney, atypical epithelioid angiomyolipoma

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Skin, benign fibrous histiocytoma, epithelioid variant

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Small bowel, metastatic melanoma

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Uterus, melanoma



Images hosted on Other servers:

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Adrenal cortical adenoma, A103+

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HMB45 and MelanA+

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Pancreas, PEComa (MelanA+)

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Skin, various images

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Skin, melanoma, sentinel lymph nodes with "stealth" metastases

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Skin, melanoma, superficial spreading

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Skin, neurotized melanocytic nevi

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Small bowel, metastatic melanoma

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Stomach metastatic melanoma, MelanA

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Testis, Leydig cell tumor



Nature images:

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Skin, dermal nevus

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Skin, melanoma, lentiginous

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Skin, melanoma, fibrohistiocytic proliferation

Positive Staining - Normal
  • Melanocytes; steroid-producing cells in adrenal cortex, ovary, testis
Positive Staining - Disease
  • Adrenal cortical adenoma and carcinoma
  • Angiomyolipoma
  • Clear cell sarcoma of soft parts (43%)
  • Nevi
  • Lymphangiomyomas
  • Melanomas: primary and metastatic, epithelioid, sinonasal
  • Paraganglioma-like dermal melanocytic tumor
  • Perivascular epihelioid cell tumors (PEComa), includes angiomyolipoma, clear cell "sugar" tumor, lymphangioleiomyomatosis, PEComas from other sites
  • Sex-cord stromal tumors
Negative Staining