Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: Maspin [title]

Definition / General
  • Tumor suppressor protein with serine protease inhibition (Serpin) activity at 18q21.3
  • Directly regulated by p53; inhibits tumor cell motility, invasion, metastasis and angiogenesis
  • Cervical squamous cell carcinoma: loss of expression from CIN 3 (HG SIL) to invasive squamous cell carcinoma (Mod Pathol 2005;18:1102)
  • Oral squamous cell carcinoma: maspin+ tumors have longer overall survival than maspin- tumors (Oncogene 2000;19:2398)
Micro Images

Nature image:

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Positive Staining - Normal
  • Breast, prostate epithelium
Positive Staining - Disease
  • Ovarian, pancreatic and gastric carcinomas
Negative Staining
  • Breast and prostate carcinomas; normal pancreas