Topic Completed: 1 March 2013

Revised: 7 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: MDM2 [title]

Nat Pernick, M.D.
Page views in 2018: 7,075
Page views in 2019 to date: 6,277
Cite this page: Pernick N. MDM2. website. Accessed September 17th, 2019.
Definition / general
  • Murine Double Minute 2
  • Protein that inhibits p53; gene is at 12q13-15
Clinical features
  • Amplified in well differentiated liposarcoma and dedifferentiated liposarcoma (amplification detected by comparative genomic hybridization, qualitative PCR, FISH; MDM2 immunostain correlates with gene amplification
  • MDM2 T309G polymorphism might be a risk factor for leukemia among Asians but not Caucasians (Leuk Lymphoma 2012;53:2245)
Uses by pathologists
  • Distinguish well differentiated liposarcoma (positive, FISH is 90% sensitive, Mod Pathol 2012;25:1384) from benign adipose tumors (negative); FISH is more sensitive than immunostains on needle biopsies (Mod Pathol 2010;23:1301)
  • Distinguish dedifferentiated liposarcoma (positive) from poorly differentiated sarcomas (negative)
  • Distinguish low grade osteosarcoma (positive) from benign fibrous and fibro-osseous lesions (negative, Mod Pathol 2011;24:624)
  • MDM2 and CDK4 coexpression in high grade osteosarcoma suggests progression from low grade osteosarcoma (Am J Surg Pathol 2012;36:423)
  • CDK4 is more specific but less sensitive than MDM2 (Am J Surg Pathol 2005;29:1340)
Microscopic (histologic) images

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Osteosarcoma, low grade

Molecular / cytogenetics images

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Dedifferentiated liposarcoma

Positive staining - disease
Negative staining
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