Author: Nat Pernick, M.D. (see Authors page)

Revised: 5 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: Melanin [title]

Definition / General
  • Pigment normally found in skin, eye, substantia nigra, melanomas
  • Melanin stains are Fontana-Masson (stains melanin black) and Schmorl method (stains melanin blue-green)
  • Bleaching with potassium permanganate or hydrogen peroxide is used to remove melanin to examine cellular morphology
  • Note: pseudomelanin of melanosis coli, usually found in macrophages, is PAS positive; true melanin is not
Micro Images
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Melanoma, Fontana-Masson stain