Stains
Melanin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 5 November 2015, last major update June 2005

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: Melanin [title]

Cite this page: Melanin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsmelanin.html. Accessed December 8th, 2016.
Definition / General
  • Pigment normally found in skin, eye, substantia nigra, melanomas
  • Melanin stains are Fontana-Masson (stains melanin black) and Schmorl method (stains melanin blue-green)
  • Bleaching with potassium permanganate or hydrogen peroxide is used to remove melanin to examine cellular morphology
  • Note: pseudomelanin of melanosis coli, usually found in macrophages, is PAS positive; true melanin is not
Micro Images
Missing Image

Melanoma, Fontana-Masson stain