Stains
Mesothelin

Author: Nat Pernick, M.D. (see Authors page)

Revised: 5 November 2015, last major update June 2005

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: Mesothelin [title]

Cite this page: Mesothelin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsmesothelin.html. Accessed December 9th, 2016.
Definition / General
  • 40 kDa differentiation antigen; precursor protein’s amino portion is megakaryocytic potentiating factor
  • Cytoplasmic membrane glycoprotein found on surface of mesothelial cells, mesothelioma, ovarian carcinoma, pancreatic adenocarcinoma
  • May place a role in cellular adhesion
Positive Staining - Normal
  • Mesothelial cells
Positive Staining - Disease
  • Mesothelioma, ovarian surface carcinoma
Negative Staining
  • Benign bile duct lesions