Author: Nat Pernick, M.D. (see Authors page)

Revised: 5 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: Mesothelin [title]

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Cite this page: Mesothelin. website. Accessed January 22nd, 2019.
Definition / general
  • 40 kDa differentiation antigen; precursor protein’s amino portion is megakaryocytic potentiating factor
  • Cytoplasmic membrane glycoprotein found on surface of mesothelial cells, mesothelioma, ovarian carcinoma, pancreatic adenocarcinoma
  • May place a role in cellular adhesion
Positive staining - normal
  • Mesothelial cells
Positive staining - disease
  • Mesothelioma, ovarian surface carcinoma
Negative staining
  • Benign bile duct lesions