Topic Completed: 1 June 2005

Minor changes: 7 March 2019

Copyright: 2002-2015,, Inc.

PubMed Search: Mesothelin [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Mesothelin. website. Accessed August 4th, 2020.
Definition / general
  • 40 kDa differentiation antigen; precursor protein’s amino portion is megakaryocytic potentiating factor
  • Cytoplasmic membrane glycoprotein found on surface of mesothelial cells, mesothelioma, ovarian carcinoma, pancreatic adenocarcinoma
  • May place a role in cellular adhesion
Positive staining - normal
  • Mesothelial cells
Positive staining - disease
  • Mesothelioma, ovarian surface carcinoma
Negative staining
  • Benign bile duct lesions
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