Table of ContentsDefinition / general
Cite this page: Hamilton K, Pernick N. Multidrug resistance associated protein (MRP). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsmrp.html. Accessed May 24th, 2019.
Definition / general
- 190kDa transmembrane phosphoglycoprotein and member of MRP / ABCC subfamily of ATP binding cassette transporters
- Overexpressed in various human multidrug resistant tumor cell lines
- Does not cross react with P-glycoprotein (mdr1, mdr3)
- MRP4: transports molecules involved in cellular signalling (Trends Pharmacol Sci 2008;29:200)