Topic Completed: 1 May 2012

Revised: 7 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: mTOR [title]

Nat Pernick, M.D.
Page views in 2018: 73
Page views in 2019 to date: 60
Cite this page: Pernick N. mTOR. website. Accessed September 22nd, 2019.
Definition / general
  • Mammalian Target Of Rapamycin
  • Also known as mechanistic target of rapamycin, FK506 binding protein 12 rapamycin associated protein 1 / FRAP1 (Wikipedia)
  • Member of PI3 kinase related family
  • Protein encoded by FRAP1 gene
  • Serine / threonine protein kinase that regulates cell growth, proliferation, motility and survival
  • Also protein synthesis and transcription
Clinical features
Uses by pathologists
  • None at this time
Microscopic (histologic) images

Images hosted on other servers:
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Positive staining - disease
  • Thyroid: papillary carcinoma (cytoplasmic and variable nuclear staining, Mod Pathol 2011;24:1553)
  • RICTOR, a major component of the mTOR complex 2, is significantly overexpressed in well differentiated leiomyosarcoma (Mod Pathol 2012;25:197)
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