Stains
mTOR

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 July 2018, last major update May 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: mTOR [title]

Cite this page: Pernick, N. mTOR. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsmtor.html. Accessed August 16th, 2018.
Definition / general
  • Mammalian Target Of Rapamycin
  • Also known as mechanistic target of rapamycin, FK506 binding protein 12 rapamycin associated protein 1 / FRAP1 (Wikipedia)
  • Member of PI3 kinase related family
  • Protein encoded by FRAP1 gene
  • Serine / threonine protein kinase that regulates cell growth, proliferation, motility and survival
  • Also protein synthesis and transcription
Clinical features
Uses by pathologists
  • None at this time
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

AKT / mTOR and ERK MAPK

Positive staining - disease
  • Thyroid: papillary carcinoma (cytoplasmic and variable nuclear staining, Mod Pathol 2011;24:1553)
  • RICTOR, a major component of the mTOR complex 2, is significantly overexpressed in well differentiated leiomyosarcoma (Mod Pathol 2012;25:197)