Stains
mTOR

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 November 2015, last major update May 2012

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: mTOR [title]

Definition / General
  • Mammalian Target Of Rapamycin
  • Also known as mechanistic target of rapamycin, FK506 binding protein 12-rapamycin associated protein 1/FRAP1 (Wikipedia)
  • Member of PI3-kinase related family
  • Protein encoded by FRAP1 gene
  • Serine / threonine protein kinase that regulates cell growth, proliferation, motility and survival
  • Also protein synthesis and transcription
Clinical Features
Uses by Pathologists
  • None at this time
Micro Images
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AKT/mTOR and ERK MAPK



Nature images:

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Chordoma

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Malignant peripheral nerve sheath tumor

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Staining results



Positive Staining - Disease
  • Thyroid: papillary carcinoma (cytoplasmic and variable nuclear staining, Mod Pathol 2011;24:1553)
  • RICTOR, a major component of the mTOR complex 2, is significantly overexpressed in well-differentiated leiomyosarcoma (Mod Pathol 2012;25:197)