Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: MUC2 [title]

Cite this page: MUC2. website. Accessed December 11th, 2018.
Definition / general
  • Epithelial mucin expressed in intestinal goblet cells and airway epithelium; gene is at 11p15.5
  • Relatively specific for predicting colorectal origin for Paget disease (Am J Surg Pathol 2001;25:1469)
  • Gel forming MUC2 mucin may act as barrier to prevent infiltration of malignant cells in breast mucinous / colloid carcinoma
Microscopic (histologic) images
Missing Image

Breast, mucinous carcinoma

Positive staining - normal
  • Intestinal and airway epithelium
Positive staining - disease
  • Mucinous carcinoma of colon, breast, pancreas, ovary and stomach
Negative staining
  • Stomach, breast ductal and lobular carcinomas