Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: MUC2 [title]

Definition / General
  • Epithelial mucin expressed in intestinal goblet cells and airway epithelium; gene is at 11p15.5
  • Relatively specific for predicting colorectal origin for Paget disease (Am J Surg Pathol 2001;25:1469)
  • Gel forming MUC2 mucin may act as barrier to prevent infiltration of malignant cells in breast mucinous / colloid carcinoma
Micro Images
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Breast, mucinous carcinoma

Positive Staining - Normal
  • Intestinal and airway epithelium
Positive Staining - Disease
  • Mucinous carcinoma of colon, breast, pancreas, ovary and stomach
Negative Staining
  • Stomach, breast ductal and lobular carcinomas