Topic Completed: 1 June 2005

Revised: 24 May 2019

Copyright: 2002-2015,, Inc.

PubMed Search: MUC4 [title]

Nat Pernick, M.D.
Page views in 2018: 2,661
Page views in 2019 to date: 3,069
Cite this page: Pernick N. MUC4 (pending). website. Accessed December 15th, 2019.
Definition / general
  • Transmembrane or membrane bound mucin that provides a protective layer of mucus
  • Normally acts as barrier to apical surface of epithelial cells, playing a protective and regulatory role
Positive staining - normal
  • Tracheobronchial mucosa, colon, stomach, cervix and lung; normal salivary glands
Positive staining - disease
  • Pancreatic, colonic, pulmonary and gastric carcinoma
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