Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: MUC4 [title]

Definition / General
  • Transmembrane or membrane bound mucin that provides a protective layer of mucus
  • Normally acts as barrier to apical surface of epithelial cells, playing a protective and regulatory role
Positive Staining - Normal
  • Tracheobronchial mucosa, colon, stomach, cervix and lung; normal salivary glands
Positive Staining - Disease
  • Pancreatic, colonic, pulmonary and gastric carcinoma