Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: MUC5AC [title]

Cite this page: MUC5AC. website. Accessed May 23rd, 2018.
Definition / general
  • Protects epithelium
Microscopic (histologic) images
Missing Image

Gastric carcinoma

Nature images:

Missing Image

Mucinous metaplasia

Missing Image


Positive staining - normal
  • Stomach (foveolar epithelium of body and antrum), tracheobronchial mucosa, endometrium (mucinous metaplasia, eosinophilic change/metaplasia (Mod Pathol 2005;18:1243), surface syncytial change, ciliated change in 52%)
Positive staining - disease
  • Extramammary Paget disease, but not mammary Paget disease or normal breast tissue (Am J Surg Pathol 2001;25:1469)
  • Mucinous carcinoma of ovary, diffuse-type gastric carcinoma (83%)
Negative staining
  • Normal breast tissue