Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: MUC5AC [title]

Definition / General
  • Protects epithelium
Micro Images
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Gastric carcinoma

Nature images:

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Mucinous metaplasia

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Positive Staining - Normal
  • Stomach (foveolar epithelium of body and antrum), tracheobronchial mucosa, endometrium (mucinous metaplasia, eosinophilic change/metaplasia (Mod Pathol 2005;18:1243), surface syncytial change, ciliated change in 52%)
Positive Staining - Disease
  • Extramammary Paget disease, but not mammary Paget disease or normal breast tissue (Am J Surg Pathol 2001;25:1469)
  • Mucinous carcinoma of ovary, diffuse-type gastric carcinoma (83%)
Negative Staining
  • Normal breast tissue