Stains
MyoD1

Author: Nat Pernick, M.D. (see Authors page)

Revised: 11 November 2015, last major update June 2005

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: MyoD1 [title]

Cite this page: MyoD1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsmyod1.html. Accessed December 4th, 2016.
Definition / General
  • Myogenic transcriptional regulatory protein expressed early in skeletal muscle differentiation
  • Sensitive but not specific for rhabdomyosarcoma due to cytoplasmic and non-specific background staining (Am J Surg Pathol 2001;25:1150)
  • Stronger staining in alveolar vs. embryonal rhabdomyosarcomasar germ cell tumors (also other cells as indicated below)
Interpretation
  • Nuclear immunostaining
Positive Staining - Normal
  • Normal fetal muscle
Negative Staining
  • Normal adult muscle