Stains
NEK2

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 November 2015, last major update November 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: NEK2 [title]

Definition / General
  • NIMA-related kinase 2 (NEK2) is a serine-threonine protein kinase which plays a major role in mitotic progression, including timing of mitotic entry, chromatin condensation, spindle organization, and cytokinesis (Cell Cycle 2013 Sep 30;12 [Epub ahead of print], GeneCards)
  • Promotes centrosome separation at G2/M transition (Eur J Cell Biol 2012;91:675)
  • Protein expression level of NEK2 is quickly degraded at the prometaphase to metaphase transition of mitosis; increased NEK2 activity during G2 phase leads to centrosome separation
  • NEK2 overexpression results in premature centrosome separation, while NEK2 mutant expression or NEK2-depleted cells lead to centrosome separation failure
Clinical Features
Uses by Pathologists
  • No significant clinical use at this time
Micro Images
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Breast, DCIS

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Breast, invasive carcinoma

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Antigen retrieval

Positive Staining - Disease