Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 November 2015, last major update September 2013

Copyright: (c) 2002-2015,, Inc.

PubMed Search: NeuN [title]

Definition / General
  • Nuclear protein (neuronal nuclear antigen) widely expressed in mature postmitotic neurons and used as a biomarker for neurons (Wikipedia)
  • Is the FOX3 gene product (J Neurosci Methods 2005;148:26)
  • Considered a marker of neuronal differentiation in brain tumors; present in all major subtypes except pilocytic astrocytoma
Uses by Pathologists
Micro Images

Images hosted on Other servers:

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Section of cortex

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Middle temporal gyral neocortex

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Neuronal density changes

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Changes in neuronal size

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Neuropathological features

Positive Staining - Normal
  • Mature postmitotic neurons
Positive Staining - Disease
Negative Staining