Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 July 2018, last major update September 2013

Copyright: (c) 2002-2018,, Inc.

PubMed Search: NeuN [title]

Page views in 2018: 922
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Cite this page: Pernick, N. NeuN. website. Accessed January 18th, 2019.
Definition / general
  • Nuclear protein (neuronal nuclear antigen) widely expressed in mature postmitotic neurons and used as a biomarker for neurons (Wikipedia)
  • Is the FOX3 gene product (J Neurosci Methods 2005;148:26)
  • Considered a marker of neuronal differentiation in brain tumors; present in all major subtypes except pilocytic astrocytoma
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:
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Section of cortex

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Middle temporal gyral neocortex

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Neuronal density changes

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Changes in neuronal size

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Neuropathological features

Positive staining - normal
  • Mature postmitotic neurons
Positive staining - disease
Negative staining