Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: NF2 [title]

Table of Contents
Definition / General
Definition / General
  • Tumor suppressor protein at 22q11-13.1
  • Produces protein called merlin or schannomin
  • Deleted in soft tissue perineurioma
  • Both copies inactivated in up to 60% of sporadic meningiomas
  • Often no protein expression in schwannoma
  • May be involved in tumorigenesis of schwannoma and some meningiomas