Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: NFKB [title]

Table of Contents
Definition / General
Definition / General
  • Nuclear Factor Kappa B
  • Transcription factor that is a heterodimer of p50 and p65/RelA
  • RelA contains TNF-alpha binding sites
  • Activated by TNF, radiation, daunorubicin
  • TNF alpha and IL-1 degrade IKB inhibitory cytoplasmic retention proteins, leading to rapid nuclear translocation of NKFB
  • Regulates cytokine inducible gene expression, including hemopoietic growth factors, chemokines and leukocyte adhesion molecules