Stains
N-myc

Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 December 2017, last major update June 2005

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: N-myc [title]

Cite this page: Pernick, N. N-myc. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsnmyc.html. Accessed May 21st, 2018.
Definition / general
  • Also called MYCN, gene at 2p24
  • Amplified gene forms double minutes and homogenously staining regions, and produces excessive N-myc protein
  • Neuroblastoma:
    • Amplification (> 10 copies by Southern blot or FISH) associated with poor prognosis and 1p36.3 deletions
Molecular / cytogenetics images

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Images kindly provided by LeicaBiosystems Amsterdam:

MYCN (2p24) / AFF3 (2q11)