Topic Completed: 1 June 2005

Revised: 7 March 2019

Copyright: 2002-2017,, Inc.

PubMed Search: N-myc [title]

Nat Pernick, M.D.
Page views in 2018: 211
Page views in 2019 to date: 178
Cite this page: Pernick N. N-myc. website. Accessed September 18th, 2019.
Definition / general
  • Also called MYCN, gene at 2p24
  • Amplified gene forms double minutes and homogenously staining regions, and produces excessive N-myc protein
  • Neuroblastoma:
    • Amplification (> 10 copies by Southern blot or FISH) associated with poor prognosis and 1p36.3 deletions
Molecular / cytogenetics images

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Images kindly provided by LeicaBiosystems Amsterdam:

MYCN (2p24) / AFF3 (2q11)

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