Nonspecific esterase

Topic Completed: 1 June 2005

Revised: 9 September 2019

Copyright: 2002-2015,, Inc.

PubMed Search: Nonspecific esterase [title]

Nat Pernick, M.D.
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Cite this page: Pernick N. Nonspecific esterase. website. Accessed September 18th, 2019.
Definition / general
  • Also called alpha-naphthyl acetate, alpha-naphthyl butyrate
  • Note:
    • Although abbreviation is NSE, is different from neuron specific esterase
    • Opposite staining for alpha-naphthyl chloroacetate esterase
Microscopic (histologic) images
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IgA myeloma

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AML M5b (fig 2)

Positive stains
  • Monocytes (inhibited by sodium fluoride), AML-M4, M5, mature T cells and T-all (cytoplasmic dot), carcinomas, megaloblastic erythrocytes, cytoplasm focally in AML-M7
Negative staining
  • AML-M0, M1, M2, M3, ALL (usually)
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