Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 10 September 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Nucleophosmin[title]
- Also called B23, numatrin; gene at 5q35
- Highly conserved non-ribosomal nucleolar phosphoprotein involved in assembling preribosomal particles into small and large ribosomal subunits; binds with high affinity to ss nucleic acids, exhibits activity that destabilizes the RNA helix and is associated with the most mature nucleolar preribosomal ribonucleoproteins
- May contribute active promoter to NPM-ALK; ALK promoter is normally silent in lymphoid cells
- IL-2 or T-cell mediated signals activate substrates; with NPM-ALK, get constitutive activation (note ALCL arises from activated T lymphocytes, which depend on IL-2 for growth and viability)
- Fusion protein found in anaplastic large cell lymphoma (13-50%); when present, can be used to differentiate from Hodgkin’s lymphoma
End of Stains > Nucleophosmin (NPM)
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