OCT 3/4

Topic Completed: 1 January 2013

Revised: 17 June 2019

Copyright: 2002-2018,, Inc.

PubMed Search: OCT4 [title] stain

Nat Pernick, M.D.
Page views in 2018: 920
Page views in 2019 to date: 4,609
Cite this page: Pernick N. OCT 3/4. website. Accessed September 22nd, 2019.
Definition / general
  • OCT 4
    • Considered the master pluripotency and embryonic stem cell regulating gene (J Ovarian Res 2012;5:37)
    • Regulates self-renewal and differentiation of embryonic stem cells, include germ cells
    • 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3
    • Also known as Octamer-binding transcription factor 4
Uses by pathologists
Microscopic (histologic) images

Contributed by Debra Zynger, M.D.


OCT 3 / 4

OCT 3 / 4

 Contributed by Epitomics
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Images hosted on other servers:
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Esophagus, squamous CC

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Lung, adenocarcinoma and SCC

Positive staining - disease
Negative staining
  • Spermatocytic seminoma
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