Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 November 2015, last major update January 2013

Copyright: (c) 2002-2015,, Inc.

PubMed Search: OCT4 [title]

Definition / General
  • Considered the master pluripotency and embryonic stem cell regulating gene (J Ovarian Res 2012;5:37)
  • Regulates self-renewal and differentiation of embryonic stem cells, include germ cells
  • 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3
  • Also known as Octamer-binding transcription factor 4
Uses by Pathologists
Micro Images
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Esophagus, squamous CC

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Lung, adenocarcinoma and SCC

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Testis, seminoma

Positive Staining - Disease
Negative Staining
  • Spermatocytic seminoma