Stains - OCT4

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Stains

OCT4

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 31 January 2013, last major update January 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: OCT4 [title]
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General
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● Considered the master pluripotency and embryonic stem cell regulating gene (J Ovarian Res 2012;5:37)
● Regulates self-renewal and differentiation of embryonic stem cells, include germ cells
● 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3
● Also known as Octamer-binding transcription factor 4

Uses by pathologists
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● Nuclear stain
● Highly sensitive and specific for primary intracranial germinomas (Am J Surg Pathol 2005;29:368)
● Poor prognostic factor for esophageal squamous cell carcinoma (World J Gastroenterol 2012;18:712)
● May be poor prognostic factor for non-small cell lung cancer (Int J Mol Sci 2012;13:7663)

Micro images
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Esophagus: squamous cell carcinoma

Lung: adenocarcinoma and squamous cell carcinoma (OCT4 and Sox2)

Testis: seminoma

Positive staining - disease
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● Lung: nonsmall cell carcinoma
● Neuroblastoma (Oncol Rep 2012;28:186)
● Ovary/Testis: dysgerminoma, embryonal carcinoma, intratubular germ cell neoplasia. seminoma, teratoma-immature neuroepithelium (Am J Surg Pathol 2010;34:1842)

Negative staining
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● Spermatocytic seminoma

End of Stains > OCT4

Ref Updated: 1/31/13

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