Stains
Oil Red O


Topic Completed: 1 June 2005

Revised: 6 March 2019

Copyright: 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Oil Red O[title]

Nat Pernick, M.D.
Page views in 2018: 693
Page views in 2019 to date: 834
Cite this page: Pernick N. Oil Red O. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsoilredo.html. Accessed July 19th, 2019.
Definition / general
  • Stain identifies neutral lipids and fatty acids
  • Fresh smears / cryostat sections of tissue are necessary because alcohols used in tissue processing remove lipids
  • Rapid and simple routine stain
  • Uses:
    1. Differentiate fibroma from thecoma (not that important a distinction)
    2. Diagnose renal cell carcinoma, sebaceous gland tumors of skin, lipid-rich carcinomas
    3. Identify fat emboli in lung tissue or clot sections of peripheral blood
Microscopic (histologic) images

Fat emboli in lung

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