Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 November 2015, last major update November 2013

Copyright: (c) 2002-2015,, Inc.

PubMed Search: Olig2 [title]

Definition / General
Clinical Features
Uses by Pathologists
Micro Images
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Pediatric glioblastoma

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Pediatric ependymoma

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Pediatric glioma, KI-67

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Pilocytic astrocytomas

Positive Staining - Disease
  • Adult gliomas: diffuse (nearly all)
  • Glioblastoma variants:
    • Giant cell (67%)
    • Gliosarcoma (93% in glial component, 14% in sarcomatous component)
    • Granular cell (100%)
    • Small cell (98%), with oligodendroglial component (100%), with PNET-like foci (74%, staining in PNET-like foci) (Mod Pathol 2013;26:315)
    Pediatric gliomas: pilocytic astrocytoma, diffuse-type astrocytic tumors (WHO grades II-IV) (J Neurooncol 2011;104:423)
  • Glioneuronal tumors: dysembryoplastic neuroepithelial tumor, papillary glioneuronal tumor, rosette-forming glioneuronal tumor of fourth ventricle (Neuropathology 2013;33:246)
  • Oligodendroglioma
Negative Staining