Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 8 January 2013, last major update January 2013
Copyright: (c) 2012-203, PathologyOutlines.com, Inc.
● Optic atrophy 1 protein (OPA1): 112 kd guanosine triphosphatase involved in mitochondrial inner membrane fusion and anticancer drug-mediated cytotoxicity
● Associated with autosomal dominant optic atrophy, characterized by selective degeneration of retinal ganglion cells (Jpn J Ophthalmol 2012;56:91, J Neurol Sci 2012;315:146)
Uses by pathologists
● No significant current use
Double labeling of hippocampal and cerebellar cells with GFAP (left) and OPA1 (right)
OPA1 expression in adult eye
Positive staining - disease
● Lung adenocarcinoma: poor prognostic factor (Hum Pathol 2012;43:105)
Electron microscopy images
Loss of OPA induces swelling and localized constrictions along mitochondria
End of Stains > OPA1
Ref Updated: 1/8/13
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