Topic Completed: 1 January 2013

Revised: 7 March 2019

Copyright: 2002-2015,, Inc.

PubMed Search: OPA1 [title]

Nat Pernick, M.D.
Page views in 2019: 19
Cite this page: Pernick N. OPA1. website. Accessed January 21st, 2020.
Definition / general
  • Optic atrophy 1 protein (OPA1): 112 kd guanosine triphosphatase involved in mitochondrial inner membrane fusion and anticancer drug-mediated cytotoxicity
  • Associated with autosomal dominant optic atrophy, characterized by selective degeneration of retinal ganglion cells (Jpn J Ophthalmol 2012;56:91, J Neurol Sci 2012;315:146)
Uses by pathologists
  • No significant current use
Positive staining - disease
Electron microscopy images
Missing Image

Loss of OPA

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