Home   Chapter Home   Jobs   Conferences   Fellowships   Books




Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 8 January 2013, last major update January 2013
Copyright: (c) 2012-203, PathologyOutlines.com, Inc.


● Optic atrophy 1 protein (OPA1): 112 kd guanosine triphosphatase involved in mitochondrial inner membrane fusion and anticancer drug-mediated cytotoxicity
● Associated with autosomal dominant optic atrophy, characterized by selective degeneration of retinal ganglion cells (Jpn J Ophthalmol 2012;56:91, J Neurol Sci 2012;315:146)

Uses by pathologists

● No significant current use

Micro images

Double labeling of hippocampal and cerebellar cells with GFAP (left) and OPA1 (right)

OPA1 expression in adult eye

Positive staining - disease

● Lung adenocarcinoma: poor prognostic factor (Hum Pathol 2012;43:105)

Electron microscopy images

Loss of OPA induces swelling and localized constrictions along mitochondria

End of Stains > OPA1

Ref Updated: 1/8/13

This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).