Author: Nat Pernick, M.D. (see Authors page)

Revised: 18 November 2015, last major update January 2013

Copyright: (c) 2002-2015,, Inc.

PubMed Search: OPA1 [title]

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Cite this page: OPA1. website. Accessed January 18th, 2019.
Definition / general
  • Optic atrophy 1 protein (OPA1): 112 kd guanosine triphosphatase involved in mitochondrial inner membrane fusion and anticancer drug-mediated cytotoxicity
  • Associated with autosomal dominant optic atrophy, characterized by selective degeneration of retinal ganglion cells (Jpn J Ophthalmol 2012;56:91, J Neurol Sci 2012;315:146)
Uses by pathologists
  • No significant current use
Positive staining - disease
Electron microscopy images
Missing Image

Loss of OPA