Stains
OSCAR cytokeratin

Author: Kara Hamilton, M.S., Nat Pernick, M.D. (see Authors page)

Revised: 12 December 2015, last major update July 2013

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: CK Oscar, Oscar Keratin
Cite this page: OSCAR cytokeratin. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsoscarkeratin.html. Accessed December 3rd, 2016.
Definition / General
  • Also called CK Oscar or Oscar Keratin
  • Interpretation: cytoplasmic staining
Uses by Pathologists
  • Broad spectrum keratin; distinguishes carcinomas from non-epithelial malignancies
Micro Images

Images hosted on Nature.com:
Missing Image

Alveolar rhabdomyosarcoma (fig B)

Positive Staining - Normal
  • Epithelium of bile ducts, bladder (urothelium), breast ducts, bronchi, colorectum, duodenum, endometrium, ileum, ovary, pancreas, prostate, stomach and thyroid
  • Also hepatocytes, pituitary acini and pneumocytes
Positive Staining - Disease
Negative Staining
  • Brain, endothelium, lymphocyte, muscle and nerves
  • GIST, lymphoma, melanoma, sarcoma and schwannoma