OSCAR cytokeratin

Topic Completed: 1 July 2013

Revised: 5 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: CK Oscar, Oscar Keratin

Nat Pernick, M.D.
Page views in 2018: 1,975
Page views in 2019 to date: 1,553
Cite this page: Hamilton K, Pernick N. OSCAR cytokeratin. website. Accessed September 23rd, 2019.
Definition / general
  • Also called CK Oscar or Oscar Keratin
  • Interpretation: cytoplasmic staining
Uses by pathologists
  • Broad spectrum keratin; distinguishes carcinomas from non-epithelial malignancies
Positive staining - normal
  • Epithelium of bile ducts, bladder (urothelium), breast ducts, bronchi, colorectum, duodenum, endometrium, ileum, ovary, pancreas, prostate, stomach and thyroid
  • Also hepatocytes, pituitary acini and pneumocytes
Positive staining - disease
Negative staining
  • Brain, endothelium, lymphocyte, muscle and nerves
  • GIST, lymphoma, melanoma, sarcoma and schwannoma
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