OSCAR cytokeratin

Author: Kara Hamilton, MS, Nat Pernick, M.D.

Revised: 24 May 2018, last major update July 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: CK Oscar, Oscar Keratin
Page views in 2018: 1,975
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Cite this page: Hamilton, K., Pernick, N. OSCAR cytokeratin. website. Accessed January 18th, 2019.
Definition / general
  • Also called CK Oscar or Oscar Keratin
  • Interpretation: cytoplasmic staining
Uses by pathologists
  • Broad spectrum keratin; distinguishes carcinomas from non-epithelial malignancies
Positive staining - normal
  • Epithelium of bile ducts, bladder (urothelium), breast ducts, bronchi, colorectum, duodenum, endometrium, ileum, ovary, pancreas, prostate, stomach and thyroid
  • Also hepatocytes, pituitary acini and pneumocytes
Positive staining - disease
Negative staining
  • Brain, endothelium, lymphocyte, muscle and nerves
  • GIST, lymphoma, melanoma, sarcoma and schwannoma