Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 July 2018, last major update December 2011

Copyright: (c) 2002-2018,, Inc.

PubMed Search: p57kip2 [title]

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Cite this page: Pernick, N. p57 kip2. website. Accessed January 22nd, 2019.
Definition / general
  • Also called CDKN1C
  • First described in 1995 (Genes Dev 1995;9:650)
  • Strongly paternally imprinted gene on 11p15.5, expressed predominantly from the maternal allele in most tissues
  • Genetic imprinting: differential DNA methylation of maternal and paternal alleles leading to allele specific expression
  • p57kip2 is potent cyclin dependent cell cycle inhibitor and tumor suppressor
  • Lack of p57 activity is associated with hyperproliferation in Beckwith-Wiedemann syndrome and complete hydatidiform mole (Hum Pathol 2002;33:1188)
  • Methylation of p16(INK4A) followed by methylation of p57(KIP2) occurs in gastric MALT lymphoma associated with H. pylori infection (Mod Pathol 2006;19:141)
  • Repressed in breast cancer cells mainly through histone modifications (PLoS One 2009;4:e5011)
  • Nuclear stain
Uses by pathologists
Microscopic (histologic) images

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Various images

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Unusual p57kip2

Positive staining - normal
  • Maternal decidua, intervillous trophoblast islands and spontaneous abortions
Positive staining - disease
  • Partial hydatidiform mole
Negative staining