Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 10 September 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: PARP[title]
- Poly (Adenoside diphosphate Ribose) Polymerase, a nuclear enzyme
- Involved in DNA repair, genome surveillance and integrity, predominantly in response to environmental stress
- Inhibits the Ca/Mg dependent endonuclease
- An immediate cellular reaction to DNA strand breakage induced by alkylating agents, ionizing radiation or oxidants; may then mediate DNA base-excision repair; also is an early step in apoptosis due to cleavage by CPP32 (caspase 3), which may lead to loss of its inhibitory effect, promoting apoptosis
Positive staining (disease)
Negative staining (disease)
- Normal melanocytes (only scattered, focal staining)
End of Stains > PARP
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