Stains
Programmed death-1 (PD-1)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2015, last major update May 2012

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: Programmed death-1 [title]


Cite this page: Programmed death-1 (PD-1). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainspd1.html. Accessed December 5th, 2016.
Definition / General
  • Also known as CD279
  • Co-inhibitory receptor of lymphocytes / other immune system cells
    • Controls lymphocyte activation by providing negative signals in conjunction with signals from lymphocyte antigen receptors (Future Oncol 2011;7:929)
  • Expressed by germinal center-associated helper T cells; inhibits T cell activity (Hum Pathol 2009;40:1715)
  • Expressed by CD8+ T cells, associated with CD8 activation (AIDS Res Hum Retroviruses 2012;28:465)
  • Has two known ligands: PD-L1 (B7H1; CD274) and PD-L2 (B7DC; CD273)
  • May limit CNS inflammation and neurologic deficits after stroke (Stroke 2011;42:2578)
Uses by Pathologists
  • Differentiate primary cutaneous CD4 small/medium-sized pleomorphic T-cell lymphoma and cutaneous pseudo-T-cell lymphomas (PD-1 positive) from other cutaneous T cell lymphomas (usually PD-1 negative, Am J Surg Pathol 2012;36:109)
  • PD-1+ rosettes of T cells around neoplastic cells is relatively specific for nodular lymphocyte-predominant Hodgkin lymphoma (Hum Pathol 2009;40:1715)
Micro Images

Images hosted on Other servers:

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Normal tonsil

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Bone marrow

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Esophageal carcinoma

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Lymph nodes

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Lymphoma, angioimmunoblastic

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Lymphoma

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Ovarian serous adenocarcinoma

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Pancreatic adenocarcinoma

Positive Staining - Normal
  • Pro-B cells
  • Germinal center-associated helper T cells
Positive Staining - Disease
Negative Staining
  • Cat-scratch disease
  • Kikuchi lymphadenitis
  • Castleman disease
  • Reactive follicular hyperplasia are PD-1 negative outside follicles (Am J Surg Pathol 2010;34:178)