Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: PDGF [title]

Page views in 2018: 161
Page views in 2019 to date: 8
Table of Contents
Definition / general
Cite this page: PDGF. website. Accessed January 17th, 2019.
Definition / general
  • Platelet Derived Growth Factor, also called c-sis
  • Produced and secreted by megakaryocytes, activated vascular endothelial cells, macrophages, fibroblasts, smooth muscle cells
  • Composed of combinations of A and B isoforms (AA, AB, BB)
  • PDGF alpha receptor binds to all 3 isoforms; PDGF beta receptor binds only to BB with high affinity
  • Chondrosarcoma: high expression of PDGF alpha receptor associated with poorer overall survival (Am J Surg Pathol 2001;25:1520)
  • Ovarian cancer: PDGF alpha receptor expression associated with shorter overall survival