Stains
PDGF

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2015, last major update June 2005

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: PDGF [title]

Table of Contents
Definition / General
Cite this page: PDGF. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainspdgf.html. Accessed December 6th, 2016.
Definition / General
  • Platelet Derived Growth Factor, also called c-sis
  • Produced and secreted by megakaryocytes, activated vascular endothelial cells, macrophages, fibroblasts, smooth muscle cells
  • Composed of combinations of A and B isoforms (AA, AB, BB)
  • PDGF alpha receptor binds to all 3 isoforms; PDGF beta receptor binds only to BB with high affinity
  • Chondrosarcoma: high expression of PDGF alpha receptor associated with poorer overall survival (Am J Surg Pathol 2001;25:1520)
  • Ovarian cancer: PDGF alpha receptor expression associated with shorter overall survival