Stains
PDGF


Topic Completed: 1 June 2005

Revised: 7 March 2019

Copyright: 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: PDGF [title]

Nat Pernick, M.D.
Page views in 2018: 161
Page views in 2019 to date: 193
Table of Contents
Definition / general
Cite this page: Pernick N. PDGF. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainspdgf.html. Accessed November 13th, 2019.
Definition / general
  • Platelet Derived Growth Factor, also called c-sis
  • Produced and secreted by megakaryocytes, activated vascular endothelial cells, macrophages, fibroblasts, smooth muscle cells
  • Composed of combinations of A and B isoforms (AA, AB, BB)
  • PDGF alpha receptor binds to all 3 isoforms; PDGF beta receptor binds only to BB with high affinity
  • Chondrosarcoma: high expression of PDGF alpha receptor associated with poorer overall survival (Am J Surg Pathol 2001;25:1520)
  • Ovarian cancer: PDGF alpha receptor expression associated with shorter overall survival
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