Stains & CD markers
PDGFRA
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: PDGFRA [title]
PDGFRA
Author: Nat Pernick, M.D.
Last author update: 1 June 2005
Last staff update: 20 August 2021
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: PDGFRA [title]
Table of Contents
Definition / generalCite this page: Pernick N. PDGFRA. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainspdgf.html. Accessed April 24th, 2024.
Definition / general
- Platelet Derived Growth Factor, also called c-sis
- Produced and secreted by megakaryocytes, activated vascular endothelial cells, macrophages, fibroblasts, smooth muscle cells
- Composed of combinations of A and B isoforms (AA, AB, BB)
- PDGF alpha receptor binds to all 3 isoforms; PDGF beta receptor binds only to BB with high affinity
- Chondrosarcoma: high expression of PDGF alpha receptor associated with poorer overall survival (Am J Surg Pathol 2001;25:1520)
- Ovarian cancer: PDGF alpha receptor expression associated with shorter overall survival
