Stains
PDS5B

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2015, last major update November 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: PDS5B [title]

Definition / General
  • Also known as APRIN (androgen-induced proliferation inhibitor) and AS3 (androgen-induced proliferation shutoff gene) [AS-3 is also an additive solution for red blood cell storage, and AS3+ is trivalent arsenite]
  • Encodes a regulatory cohesion protein that interacts with the conserved protein complex termed cohesion
    • The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis (GeneCards - PDS5B)
  • Considered a putative tumor suppressor gene
  • Required for normal response to DNA damaging agents, the nuclear localisation of RAD51 and BRCA2, and efficient homologous recombination (EMBO J 2012;31:1160)
  • Required for androgen dependent growth arrest, and is a primary target for 1,25(OH)(2)D(3) and androgens (Prostate 2005;64:362)
Clinical Features
  • Colorectal / gastric carcinomas with high microsatellite instability: frameshift mutations in 20% (associated with loss of staining, Hum Pathol 2013;44:2234)
  • Upregulated in ventricular septum tissues from patients with ventricular septal defect
  • Expression associated with outcome of breast cancer patients treated with DNA damaging chemotherapy
Uses by Pathologists
  • No specific uses as this time