Cite this page: Pernick N. PHF1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsphf1.html. Accessed March 23rd, 2019.
Definition / general
- Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis (J Biol Chem 2013;288:529)
- PHF1 gene rearrangement present in 80% of ossifying fibromyxoid tumors (benign, atypical and malignant lesions, Am J Pathol 2012;181:1069, Am J Surg Pathol 2013;37:1751), with fusion to EP400 in 44% of cases (Genes Chromosomes Cancer 2014;53:183)
- Endometrial stromal sarcoma with sex cord differentiation is associated with PHF1 rearrangement (Am J Surg Pathol 2013;37:514)
- Unusual ossifying sarcoma of the heart demonstrated JAZF1 / PHF1 fusion (Am J Surg Pathol 2013;37:938)
Uses by pathologists
- No uses at this time