Phosphohistone H3

Author: Nat Pernick, M.D. (see Authors page)

Revised: 24 July 2018, last major update June 2005

Copyright: (c) 2002-2018,, Inc.

PubMed Search: Phosphohistone H3 [title]

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Cite this page: Pernick, N. Phosphohistone H3. website. Accessed January 22nd, 2019.
Definition / general
  • Core histone protein that is major constituent of chromatin; marker of cells in late G2 and M phase
  • Nuclear stain
  • Count phosphohistone H3+ objects (nuclei and mitoses) in 10 adjacent fields with 40x objective, in invasive epithelial areas with highest phosphohistone H3 staining
  • Ignore nuclei with fine granular staining
Uses by pathologists
Microscopic (histologic) images

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Normal colonic mucosa

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Ki67, phosphohistone H3 and survivin

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Grade 3 breast carcinoma

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Thick cutaneous melanomas

Positive staining - disease
  • Mitotic activity