Stains
Phosphohistone H3


Topic Completed: 1 June 2005

Revised: 8 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Phosphohistone H3 [title]

Nat Pernick, M.D.
Page views in 2018: 839
Page views in 2019 to date: 1,103
Cite this page: Pernick N. Phosphohistone H3. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsphosphohistoneh3.html. Accessed November 13th, 2019.
Definition / general
  • Core histone protein that is major constituent of chromatin; marker of cells in late G2 and M phase
Interpretation
  • Nuclear stain
  • Count phosphohistone H3+ objects (nuclei and mitoses) in 10 adjacent fields with 40x objective, in invasive epithelial areas with highest phosphohistone H3 staining
  • Ignore nuclei with fine granular staining
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:
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Normal colonic mucosa

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Ki67, phosphohistone H3 and survivin

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Grade 3 breast carcinoma

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Thick cutaneous melanomas

Positive staining - disease
  • Mitotic activity
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