Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 29 September 2013, last major update June 2005
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
PubMed Search: Phosphohistone H3[title]
- Core histone protein that is major constituent of chromatin; marker of cells in late G2 and M phase
- Nuclear stain; count phosphohistone H3+ objects (nuclei and mitoses) in 10 adjacent fields with 40x objective, in invasive epithelial areas with highest phosphohistone H3 staining; ignore nuclei with fine granular staining
Uses by pathologists
Ki-67, phosphohistone H3 and survivin
Node negative breast cancer
Thick cutaneous melanomas
Positive staining - disease
End of Stains > Phosphohistone H3
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