Topic Completed: 1 June 2005

Minor changes: 8 March 2019

Copyright: 2002-2018,, Inc.

PubMed Search: PLEKHA7 [title]

Nat Pernick, M.D.
Page views in 2019: 61
Page views in 2020 to date: 19
Cite this page: Pernick N. PLEKHA7. website. Accessed May 29th, 2020.
Definition / general
  • Pleckstrin-homology-domain-containing protein
  • PLEKHA7, cingulin and paracingulin are proteins localized in cytoplasmic region of apical junctional complex of vertebrate epithelial cells
  • PLEKHA7, together with paracingulin, is part of a protein complex that links E-cadherin to microtubule cytoskeleton adherens junctions
    • PLEKHA7 overexpression has inverse relation with E-cadherin expression
Clinical features
Uses by pathologists
  • PLEKHA7 overexpression may differentiate infiltrating lobular carcinoma from normal tissue / low grade infiltrating ductal carcinoma (PLEKHA7-, Hum Pathol 2012;43:1902)
Microscopic (histologic) images

Images hosted on other servers:
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Various images

Positive staining - disease
  • Breast: infiltrating lobular carcinoma
  • Various (ProteinAtlas)
Negative staining
  • Breast: normal, infiltrating ductal carcinoma
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