Stains
PLEKHA7

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 December 2015, last major update June 2005

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: PLEKHA7 [title]

Definition / General
  • Pleckstrin-homology-domain-containing protein
  • PLEKHA7, cingulin and paracingulin are proteins localized in cytoplasmic region of apical junctional complex of vertebrate epithelial cells
  • PLEKHA7, together with paracingulin, is part of a protein complex that links E-cadherin to microtubule cytoskeleton adherens junctions
    • PLEKHA7 overexpression has inverse relation with E-cadherin expression
Clinical Features
Uses by Pathologists
  • PLEKHA7 overexpression may differentiate infiltrating lobular carcinoma from normal tissue / low grade infiltrating ductal carcinoma (PLEKHA7-, Hum Pathol 2012;43:1902)
Micro Images
Missing Image Missing Image

Various images

Positive Staining - Disease
  • Breast: infiltrating lobular carcinoma
  • Various (ProteinAtlas)
Negative Staining
  • Breast: normal, infiltrating ductal carcinoma