Author: Nat Pernick, M.D. (see Authors page)

Revised: 24 July 2018, last major update June 2005

Copyright: (c) 2002-2018,, Inc.

PubMed Search: PLEKHA7 [title]

Page views in 2018: 41
Page views in 2019 to date: 4
Cite this page: Pernick, N. PLEKHA7. website. Accessed January 18th, 2019.
Definition / general
  • Pleckstrin-homology-domain-containing protein
  • PLEKHA7, cingulin and paracingulin are proteins localized in cytoplasmic region of apical junctional complex of vertebrate epithelial cells
  • PLEKHA7, together with paracingulin, is part of a protein complex that links E-cadherin to microtubule cytoskeleton adherens junctions
    • PLEKHA7 overexpression has inverse relation with E-cadherin expression
Clinical features
Uses by pathologists
  • PLEKHA7 overexpression may differentiate infiltrating lobular carcinoma from normal tissue / low grade infiltrating ductal carcinoma (PLEKHA7-, Hum Pathol 2012;43:1902)
Microscopic (histologic) images

Images hosted on other servers:
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Various images

Positive staining - disease
  • Breast: infiltrating lobular carcinoma
  • Various (ProteinAtlas)
Negative staining
  • Breast: normal, infiltrating ductal carcinoma