Stains
PPAR γ

Author: Nat Pernick, M.D. (see Authors page)

Revised: 14 December 2015, last major update January 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: PPAR gamma [title]

Definition / General
  • Peroxisome Proliferator Activated Receptor γ
  • PAX8 / PPARγ fusion protein is produced by t(2;3)(q13;p25), occurs frequently in follicular thyroid carcinoma; diffuse strong nuclear staining correlates with PAX8-PPARγ detected by RT-PCR in follicular carcinoma or adenoma (Am J Surg Pathol 2002;26:1016)
  • PPARγ agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function, and may protect against neurodegenerative changes associated with neuroinflammation (J Neuroinflammation 2012;9:63, Mol Neurobiol 2012;46:114)
  • Decreases inflammatory response of many cardiovascular cells, particularly endothelial cells
  • Controls adipocyte differentiation and regulates many genes associated with energy homeostasis
    • Its gene polymorphisms influence obesity and obesity phenotype in a complex manner, probably involving insulin resistance in north Indian population (Am J Hum Biol 2012;24:454)
Uses by Pathologists
  • No significant uses at this time
Micro Images

Nature images:

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Various images

Positive Staining - Normal
  • High expression in fat, low expression in liver, very low expression in muscle