Stains
Prostate specific membrane antigen (PSMA)

Author: Sheren Younes, M.D. (see Authors page)

Revised: 24 July 2018, last major update August 2016

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Prostate specific membrane antigen [title]

Cite this page: Younes, S. Prostate specific membrane antigen (PSMA). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainspsma.html. Accessed September 22nd, 2018.
Definition / general
  • 750 Amino acid, 100 KDa, type II membrane glycoprotein with both folate hydrolase and N-acetylated-alpha-linked-acidic peptidase (NAALAD) activity
  • Assists with folate uptake and modulates excitatory neurotransmissions in brain
  • In contrast to PSA, upregulated with androgen deprivation (Rev Urol 2004;6:S13)
Diagrams / tables

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PSA vs. PSMA

Uses by pathologists
Interpretation
  • Cytoplasmic or membranous staining
Positive staining - normal
  • Prostate epithelial cells; also adrenal gland, bladder, breast, esophagus, fallopian tube, kidney, large intestine, liver, ovary, small intestine, spinal cord, stomach, testis
Negative staining - normal
  • Prostate basal and stromal cells
Positive staining - tumors