Stains
Prostate specific membrane antigen (PSMA)



Topic Completed: 1 August 2016

Revised: 28 February 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: Prostate specific membrane antigen [title]


Sheren Younes, M.D.
Page views in 2018: 779
Page views in 2019 to date: 492
Cite this page: Younes S. Prostate specific membrane antigen (PSMA). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainspsma.html. Accessed June 17th, 2019.
Definition / general
  • 750 Amino acid, 100 KDa, type II membrane glycoprotein with both folate hydrolase and N-acetylated-alpha-linked-acidic peptidase (NAALAD) activity
  • Assists with folate uptake and modulates excitatory neurotransmissions in brain
  • In contrast to PSA, upregulated with androgen deprivation (Rev Urol 2004;6:S13)
Diagrams / tables

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PSA vs. PSMA

Uses by pathologists
Interpretation
  • Cytoplasmic or membranous staining
Positive staining - normal
  • Prostate epithelial cells; also adrenal gland, bladder, breast, esophagus, fallopian tube, kidney, large intestine, liver, ovary, small intestine, spinal cord, stomach, testis
Negative staining - normal
  • Prostate basal and stromal cells
Positive staining - tumors
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