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Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 12 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.


● Ets family transcription factor, also known as Spleen focus forming virus Proviral Integration site-1 (Spi1)
● Transcription factor that plays an essential role in development of lymphoid and myeloid cells by regulating IL7 receptor or macrophage-colony stimulating factor; low PU.1 levels upregulate IL7 receptor expression on common lymphoid progenitor cells, while high levels of PU.1 prevent IL7 receptor expression
● PU.1 expression is dynamically controlled throughout haematopoiesis to direct appropriate lineage specification (Int J Cell Biol 2011;2011:808524)
● Nuclear staining

Uses by pathologists

● Differentiate classic Hodgkin lymphoma (PU.1 negative) from nodular lymphocyte predominant Hodgkin lymphoma (PU.1+, Mod Pathol 2006;19:1010)

Micro images

Histiocytic sarcoma (figures C, D)

Left: B-ALL (figure E); right: T-ALL (figure C)

Positive staining - disease

● Nodular lymphocyte predominant Hodgkin lymphoma (100%)
● Follicular lymphoma, mantle cell lymphoma, marginal zone B-cell lymphoma, small lymphocytic lymphoma (100%)
● Histiocytic / dendritic cell sarcoma (100%, Mod Pathol 2011;24:1421)
● 50% of diffuse large B cell lymphoma

Negative staining

● Classical Hodgkin's lymphoma (Reed-Sternberg and Hodgkin cells)
● Downregulated in CML (Int J Hematol 2012 Jun 7 [Epub ahead of print])

End of Stains > PU.1

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