Stains
PU.1


Topic Completed: 1 June 2012

Revised: 8 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: PU.1 [title]

Nat Pernick, M.D.
Page views in 2018: 308
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Cite this page: Pernick N. PU.1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainspu1.html. Accessed December 13th, 2019.
Definition / general
  • Ets family transcription factor, also known as Spleen focus forming virus Proviral Integration site-1 (Spi1)
  • Transcription factor that plays an essential role in development of lymphoid and myeloid cells by regulating IL7 receptor or macrophage-colony stimulating factor
    • Low PU.1 levels upregulate IL7 receptor expression on common lymphoid progenitor cells, while high levels of PU.1 prevent IL7 receptor expression
  • PU.1 expression is dynamically controlled throughout haematopoiesis to direct appropriate lineage specification (Int J Cell Biol 2011;2011:808524)
  • Nuclear staining
Uses by pathologists
  • Differentiate classic Hodgkin lymphoma (PU.1 negative) from nodular lymphocyte predominant Hodgkin lymphoma (PU.1+, Mod Pathol 2006;19:1010)
Microscopic (histologic) images

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Histiocytic sarcoma

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B ALL and T ALL

Positive staining - disease
  • Nodular lymphocyte predominant Hodgkin lymphoma (100%)
  • Follicular lymphoma, mantle cell lymphoma, marginal zone B cell lymphoma, small lymphocytic lymphoma (100%)
  • Histiocytic / dendritic cell sarcoma (100%, Mod Pathol 2011;24:1421)
  • 50% of diffuse large B cell lymphoma
Negative staining
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