Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 December 2015, last major update July 2013

Copyright: (c) 2003-2015,, Inc.

Definition / General
  • Plays major role in homologous recombination of DNA during double strand break repair (Wikipedia, GeneCards)
  • Disassembles nucleosomes by unwrapping DNA from histones (Nucleic Acids Res 2013;41:7302)
  • Interacts with BRCA2 and BRCA1
  • Protein highly conserved in most eukaryotes, from yeast to humans
Diagrams / Tables

Interaction with BRCA2

Micro Images

Prostate adenocarcinoma