Stains
Reg IV

Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update December 2011

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: reg iv
Definition / General
  • Member of Regenerating protein family, which was originally isolated from regenerating rat pancreatic islets (J Biol Chem 1988;263:2111)
  • Group of small, multifunctional secreted proteins, which can function as acute phase reactants, anti-apoptotic or growth agents (Cancer Biol Ther 2007;6:123)
  • REG family members have tropic effect on islets and gastric epithelial cells
  • REG IV leads to increased resistance to apoptotic cell death in colorectal carcinoma (Cancer Biol Ther 2006;5:1714)
Terminology
  • Four members identified to date in humans: I alpha, I beta, III and IV
  • Also called RELP
Pathophysiology
  • Potent activator of EGFR receptor/Akt/AP-1 signaling pathway in colon cancer cells
  • Closely linked with inhibition of apoptosis
  • Uprelated in gastric intestinal metaplasia and adenoma (Hum Pathol 2010;41:59)
Uses by Pathologists
  • No significant uses at this time
Micro Images

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Prostate: normal and carcinoma



Images hosted on Nature.com:
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Colon ISH: normal colon, ulcerative colitis, dysplasia, carcinoma

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Gastric cancer

Positive Staining - Normal
  • Constitutively expressed in neuroendocrine cells of intestinal mucosa
Positive Staining - Disease
Negative Staining