Reg IV

Topic Completed: 1 December 2011

Revised: 8 March 2019

Copyright: 2003-2018,, Inc.

PubMed Search: reg iv

Nat Pernick, M.D.
Page views in 2019: 29
Page views in 2020 to date: 1
Cite this page: Pernick N. Reg IV. website. Accessed January 24th, 2020.
Definition / general
  • Member of Regenerating protein family, which was originally isolated from regenerating rat pancreatic islets (J Biol Chem 1988;263:2111)
  • Group of small, multifunctional secreted proteins, which can function as acute phase reactants, anti-apoptotic or growth agents (Cancer Biol Ther 2007;6:123)
  • REG family members have tropic effect on islets and gastric epithelial cells
  • REG IV leads to increased resistance to apoptotic cell death in colorectal carcinoma (Cancer Biol Ther 2006;5:1714)
  • Four members identified to date in humans: I alpha, I beta, III and IV
  • Also called RELP
  • Potent activator of EGFR receptor/Akt/AP-1 signaling pathway in colon cancer cells
  • Closely linked with inhibition of apoptosis
  • Uprelated in gastric intestinal metaplasia and adenoma (Hum Pathol 2010;41:59)
Uses by pathologists
  • No significant uses at this time
Microscopic (histologic) images

Images hosted on other servers:

Prostate: normal and carcinoma

Missing Image

Colon ISH: normal colon, ulcerative colitis, dysplasia, carcinoma

Positive staining - normal
  • Constitutively expressed in neuroendocrine cells of intestinal mucosa
Positive staining - disease
Negative staining
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