Reg IV

Author: Nat Pernick, M.D. (see Authors page)

Revised: 8 August 2018, last major update December 2011

Copyright: (c) 2003-2018,, Inc.

PubMed Search: reg iv
Cite this page: Pernick, N. Reg IV. website. Accessed October 20th, 2018.
Definition / general
  • Member of Regenerating protein family, which was originally isolated from regenerating rat pancreatic islets (J Biol Chem 1988;263:2111)
  • Group of small, multifunctional secreted proteins, which can function as acute phase reactants, anti-apoptotic or growth agents (Cancer Biol Ther 2007;6:123)
  • REG family members have tropic effect on islets and gastric epithelial cells
  • REG IV leads to increased resistance to apoptotic cell death in colorectal carcinoma (Cancer Biol Ther 2006;5:1714)
  • Four members identified to date in humans: I alpha, I beta, III and IV
  • Also called RELP
  • Potent activator of EGFR receptor/Akt/AP-1 signaling pathway in colon cancer cells
  • Closely linked with inhibition of apoptosis
  • Uprelated in gastric intestinal metaplasia and adenoma (Hum Pathol 2010;41:59)
Uses by pathologists
  • No significant uses at this time
Microscopic (histologic) images

Images hosted on other servers:

Prostate: normal and carcinoma

Missing Image

Colon ISH: normal colon, ulcerative colitis, dysplasia, carcinoma

Positive staining - normal
  • Constitutively expressed in neuroendocrine cells of intestinal mucosa
Positive staining - disease
Negative staining