Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 4 November 2013, last major update September 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: ROS1[title]
- Repressor of Silencing 1 (ROS1) is a receptor tyrosine kinase that undergoes genetic rearrangements in various human cancers (Clin Cancer Res 2013;19:4040)
- ROS1 gene rearrangements are reported in 1% to 2% of lung adenocarcinomas (Am J Surg Pathol 2013;37:554, Oncologist 2013;18:865), are associated with higher response rates to therapies including crizotinib (Ann Oncol 2013;24:2364, Clin Cancer Res 2012;18:4570)
- CD74-ROS1 fusion is involved in carcinogenesis of non small cell lung cancer subset (Oncol Rep 2013;30:1675); also angiosarcoma, cholangiocarcinoma, colorectal cancer, epithelioid hemangioendothelioma, gastric adenocarcinoma (Cancer 2013;119:1627),, glioblastoma, inflammatory myofibroblastic tumor, ovarian cancer
Uses by pathologists
Invasive ductal carcinoma (ROS1+, fig B)
Non small cell lung cancer
ROS1 rearranged lung tumors
End of Stains > ROS1
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