Stains
RUNX1



Topic Completed: 1 July 2012

Revised: 8 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: runx1
Page views in 2018: 29
Page views in 2019 to date: 25
Cite this page: Pernick N. RUNX1. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsrunx1.html. Accessed May 24th, 2019.
Definition / general
  • Transcription factor RUNt-related transcription factor ("X") 1
  • Also called core-binding factor subunit alpha-2 (CBFA2); previously called AML1
  • Heterodimeric transcription factor that binds to core element of many enhancers and promoters; protein encoded by this gene represents the alpha subunit of CBF (NCBI-Gene)
  • Essential for establishment of definitive hematopoiesis during embryonic development
  • Obligate non-DNA binding partner is core binding factor β (CBFβ)
  • In adult blood homeostasis, plays pivotal role in maturation of lymphocytes and megakaryocytes (Nat Commun 2012;3:717); also required for regulation of hematopoietic stem and progenitor cells (Blood 2012;119:4152)
  • Also important in neuronal differentiation (PLoS One 2012;7:e29852)
  • Disruption of RUNX1 function is major cause of hematopoietic malignancy, including myelodysplastic syndromes and AML (Haematologica 2012;97:534)
  • Genes for RUNX1 and CBFβ are targeted by translocations important in AML (Crit Rev Oncog 2011;16:77)
Clinical features
Uses by pathologists
  • Important in classifying hematopoietic malignancies
Microscopic (histologic) images

Images hosted on other servers:

Importance of RUNX1 in
establishment of definitive
hematopoiesis during
embryonic development

Positive staining - normal
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