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Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 7 December 2011, last major update December 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.


● 95 amino acid calcium-binding protein first purified from placenta in 1992 (Eur J Biochem 1992;207:541); 95 amino acid calcium-binding protein; may initiate carcinogenesis in some epithelial tumors
● Caution: S100 (the neural / melanocytic marker) is also described as S100p or S100P in the literature


● Intracellular S100P interacts with ezrin, and extracellular S100P activates the receptor for advanced glycation endproducts
● Associated with aggressive disease in peripheral intrahepatic cholangiocarcinoma (Am J Surg Pathol 2011;35:590)


● Nuclear and cytoplasmic staining

Uses by Pathologists

● Diagnose pancreatic adenocarcinoma in FNA specimens (Am J Clin Pathol 2008;129:81, Diagn Cytopathol 2011 Apr 28 [Epub ahead of print])
● Differentiate bile duct adenocarcinoma from reactive lesions at biopsy, as part of a immunohistochemical panel with pVHL and IMP3 (Hum Pathol 2010;41:1210)
● Differentiate urothelial carcinoma (S100P+ in 78-86%) from prostatic adenocarcinoma (S100P-)
● Possible biological indicator (due to downregulation) of cadmium toxicity in placentas (Sci Total Environ 2011;410:53)

Micro images

Various normal tissues

Left: colon dysplasia and carcinoma; right - various carcinomas

Pancreas: normal, PanIN, adenocarcinoma

Positive staining - normal

● mRNA - high levels: esophagus and placenta; mRNA - moderate levels: colon, duodenum, prostate, stomach, white blood cells (BMC Clin Pathol 2008 Feb 18;8:2)
● Protein - high levels: placenta and stomach

Positive staining - disease

● GI, liver, lung carcinomas
● Ovarian carcinoma and ovarian Brenner tumors (Am J Surg Pathol 2009;33:347)
● Pancreatic ductal adenocarcinoma (56%), PanIN (90%, Am J Surg Pathol 2008;32:78), IPMN (Hum Pathol 2010;41:824)
● Salivary glands-carcinoma ex pleomorphic adenoma (Am J Surg Pathol 2011;35:346)
● Urothelial carcinoma (78-86%, Am J Surg Pathol 2007;31:673)

Negative staining

● Pancreas (normal), prostatic adenocarcinoma, renal cell carcinoma

End of Stains > S100P

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