Stains
S100P

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 December 2015, last major update December 2011

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

Cite this page: S100P. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainss100p.html. Accessed December 10th, 2016.
Definition / General
  • 95 amino acid calcium-binding protein first purified from placenta in 1992 (Eur J Biochem 1992;207:541); 95 amino acid calcium-binding protein; may initiate carcinogenesis in some epithelial tumors
  • Caution: S100 (the neural / melanocytic marker) is also described as S100p or S100P in the literature
Pathophysiology
  • Intracellular S100P interacts with ezrin, and extracellular S100P activates the receptor for advanced glycation endproducts
  • Associated with aggressive disease in peripheral intrahepatic cholangiocarcinoma (Am J Surg Pathol 2011;35:590)
Interpretation
  • Nuclear and cytoplasmic staining
Uses by Pathologists
Micro Images

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Various normal tissues

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Left: colon dysplasia and carcinoma; right - various carcinomas

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Pancreas: normal, PanIN, adenocarcinoma

Positive Staining - Normal
  • mRNA - high levels: esophagus and placenta; mRNA - moderate levels: colon, duodenum, prostate, stomach, white blood cells (BMC Clin Pathol 2008 Feb 18;8:2)
  • Protein - high levels: placenta and stomach
Positive Staining - Disease
Negative Staining
  • Pancreas (normal), prostatic adenocarcinoma, renal cell carcinoma