Topic Completed: 1 December 2011

Revised: 10 March 2020

Copyright: 2002-2020,, Inc.

PubMed Search: SALL4[TI]

Nat Pernick, M.D.
Page views in 2019: 6,644
Page views in 2020 to date: 1,889
Cite this page: Pernick N. SALL4. website. Accessed March 31st, 2020.
Definition / general
  • First characterized in 2002 (Hum Mol Genet 2002;11:2979); stem cell marker and oncofetal protein similar to alpha-fetoprotein and glycipan3
  • Zinc-finger transcriptional factor important for embryonic development, at 20q13
  • Maintains stem cell identity and governs stem cell self-renewal through transcriptional repression, possibly through repression of different DNA methyltransferases (J Biol Chem 2012;287:1996)
Clinical features
  • SALL4-related disorders include Duane-radial ray syndrome and acro-renal-ocular syndrome (GeneReviews [Internet])
  • Nuclear staining
Uses by pathologists
Microscopic (histologic) images

Images hosted on other servers:
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CNS tumors: germinoma and embryonal carcinoma

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Staining of CD34+ hematopoietic stem /
progenitor cells, AML, B lymphoblastic
leukemia / lymphoma but not T cell
lymphoblastic leukemia / lymphoma

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No staining of normal lymph nodes, tonsil, thymus

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No staining of follicular
lymphoma, Burkitt
lymphoma, Hodgkin
lymphoma, myeloma

Positive staining - normal
  • Fetal stomach at gestational week 9 only; CD34+ hematopoietic stem/progenitor cells
Positive staining - disease
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