Stains
Special AT-rich sequence-binding protein 2 (SATB2)

Author: Angela Chan, MSc. (see Authors page)
Editor: Emeka Enwere, M.D.

Revised: 13 March 2017, last major update February 2017

Copyright: (c) 2017, PathologyOutlines.com, Inc.

PubMed Search: Special AT-rich sequence-binding protein 2 OR SATB2
Cite this page: Special AT-rich sequence-binding protein 2 (SATB2). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainssatb2.html. Accessed December 15th, 2017.
Definition / general
  • Regulates transcription and chromatin remodeling
  • Binds to matrix attachment regions (MAR) of DNA and induces a local chromatin loop remodeling
Sites
Pathophysiology
  • Contains 2 consensus SUMO acceptor sites
  • Can be sumoylated by SUMO E3 Ligase PIAS1
  • Defects in sumoylation sites is associated with gene activation and SATB2 is targeted to nuclear periphery upon sumoylation (Genes Dev 2003;17:3048)
  • Mutant SATB2 has a dominant-negative effect on wild type protein (Hum Genet 2013;132:1383)
  • Involved in vertebrate skeletogenesis via repression of HOXA2 gene (inhibitor of bone formation and regulator of branchial arch patterning) (Cell 2006;125:971)
  • SATB2 knockout mice show defects in osteoblast differentiation via interaction to RUNX2 and ATF4 (transcription factors that regulate osteoblast differentiation) (Cell 2006;125:971, Stem Cells Dev 2013;22:2278)
Diagrams / tables

Images hosted on other servers:

Comparison of clinical features of patients

SATB2 and Cancer

Clinical features
Uses by pathologists
Prognostic factors
Case reports
Clinical images

Images hosted on other servers:

3 year old patient with SATB2 R239X mutation

10 year old patient showing mild dysmorphic features

Microscopic (histologic) images

Images hosted on other servers:

Immunohistochemical
images of SATB2
staining in CRC

Virtual slides

Images hosted on other servers:

Various images

Positive stains
  • Brain
  • Branchial arch
  • Sites of bone formation
  • Kidney
  • Gut
  • Colon
  • Lymphoid cells
Negative stains
  • Liver
  • Lung
  • Pancreas