Selectin P / CD62P

Author: Nat Pernick, M.D. (see Authors page)

Revised: 29 December 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: P-Selectin[title]

Selectins: Selectin-E (CD62E)Selectin-L (CD62L)  Selectin-P (CD62P)-below
Cite this page: Selectin P. website. Accessed October 28th, 2016.
Definition / General
  • Also called CD62P, PADGEM, SELP
  • Interaction with CD162 mediates tethering and rolling of leukocytes on the surface of activated endothelial cells
  • Mediates delivery of lymphocytes to high endothelial venules (with CD62L)
  • A platelet alpha-granule membrane protein that redistributes to the plasma membrane during platelet activation and degranulation
  • Has procoagulant activity (Trends Mol Med 2004;10:179)
  • Constitutive expression in inflammation may contribute to tissue destruction, atherogenesis and thrombosis
  • Reduced expression in gray platelet syndrome (OMIM #139090), advanced melanoma (Am J Pathol 1998;152:679)
  • Increased expression in Takayasu's arteritis (Circ J 2006;70:600)
  • Increased serum levels associated with atherosclerosis (Eur Heart J 2003;24:2166)
  • Val640Leu polymorphism is associated with thromboembolic stroke (Hum Mol Genet 2004;13:389)
  • Endothelial P-selectin has important role in pathogenesis of cerebral malaria (Am J Pathol 2004;164:781)
  • Promotes metastases by tumor cell binding (Glycobiology 2007;17:185)
Uses by Pathologists
Micro Images

Images hosted on other servers:

Megakaryocytes in bone marrow

Positive Staining - Normal
  • Platelets, megakaryocytes, activated endothelial cells (membranes of Weibel-Palade bodies)
Negative Staining - Normal
Additional References