Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 August 2018, last major update October 2013

Copyright: (c) 2013-2018,, Inc.

PubMed Search: SGOL1

Cite this page: Pernick, N. SGOL1. website. Accessed October 20th, 2018.
Definition / general
  • Shugoshin-like 1 (SGOL1) is a key protein in protecting sister chromatids from precocious separation, and a putative tumor suppressor gene (Oncogene 2011;30:4453, GeneCards)
  • Complex of shugoshin and protein phosphatase 2A (SGO1-PP2A) protects cohesin, a protein complex that regulates chromatid cohesion, helps prevent aneuploidy and maintains chromosomal stability (Nat Cell Biol 2013;15:40, Cell Cycle 2007;6:1579)
  • Frameshift mutations and loss of expression are associated with gastric and colorectal cancers with high microsatellite instability (Hum Pathol 2013;44:2234)
  • Enhances multidrug resistance of gastric cancer cells by regulating MRP1, Bcl2, and Bax genes (Tumour Biol 2013;34:2205)
Uses by pathologists
  • No uses at this time
Microscopic (histologic) images

Images hosted on other servers:

Testis: seminiferus ducts

Breast cancer

Cervical cancer

Colorectal cancer


Head and neck cancer

Kidney cancer

Liver cancer

Lung cancer



Ovarian cancer

Pancreatic cancer

Prostate cancer

Skin cancer

Stomach cancer

Testis cancer

Thyroid cancer

Urothelial cancer

Uterus: endometrial cancer