Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 December 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: SHP-1[title]

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Cite this page: SHP-1. website. Accessed January 19th, 2019.
Definition / general
  • Also called Srk Homology domain 2 containing Protein phosphatase 1
  • Non-transmembrane protein phosphotyrosine phosphatase
  • Modulates intracellular signaling for various molecules
  • Preliminary study suggests helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative), Am J Surg Pathol 2001;25:949
Positive staining - normal
  • Mantle zone, marginal zone, interfollicular zone of lymph node
Positive staining - disease
  • Mantle cell lymphoma, marginal zone lymphoma, SLL/CLL
Negative staining
  • Germinal centers (or weak), follicular lymphomas