Topic Completed: 1 June 2005

Revised: 8 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: SHP-1[title]

Nat Pernick, M.D.
Page views in 2019: 17
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Cite this page: Pernick N. SHP-1. website. Accessed February 27th, 2020.
Definition / general
  • Also called Srk Homology domain 2 containing Protein phosphatase 1
  • Non-transmembrane protein phosphotyrosine phosphatase
  • Modulates intracellular signaling for various molecules
  • Preliminary study suggests helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative), Am J Surg Pathol 2001;25:949
Positive staining - normal
  • Mantle zone, marginal zone, interfollicular zone of lymph node
Positive staining - disease
  • Mantle cell lymphoma, marginal zone lymphoma, SLL/CLL
Negative staining
  • Germinal centers (or weak), follicular lymphomas
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