Stains
Sialyl-Tn antigen

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 December 2015, last major update June 2005

Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.

PubMed Search: Sialyl-Tn antigen[title]

General
  • Also called CD175s
  • Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
  • Presence associated with aggressive tumors
  • High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
  • Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
Positive Staining - Disease
  • Carcinomas