Sialyl-Tn antigen

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 December 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: Sialyl-Tn antigen[title]

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Cite this page: Sialyl-Tn antigen. website. Accessed January 22nd, 2019.
Definition / general
  • Also called CD175s
  • Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
  • Presence associated with aggressive tumors
  • High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
  • Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
Positive staining - disease
  • Carcinomas