Sialyl-Tn antigen

Topic Completed: 1 June 2005

Revised: 8 March 2019

Copyright: 2003-2015,, Inc.

PubMed Search: Sialyl-Tn antigen[title]

Nat Pernick, M.D.
Page views in 2018: 13
Page views in 2019 to date: 11
Cite this page: Pernick N. Sialyl-Tn antigen. website. Accessed September 20th, 2019.
Definition / general
  • Also called CD175s
  • Carbohydrate associated with apomucins MUC1, MUC2; produced in the initial steps of mucin biosynthetic pathway
  • Presence associated with aggressive tumors
  • High pre-operative serum levels predict liver metastasis and poor prognosis after resection for gastric cancer
  • Definitive Phase III trial of STN vaccine in metastatic breast cancer patients began 2001
Positive staining - disease
  • Carcinomas
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